Can ceramides cause insulin resistance?

I asked a similar question like this before, and it got no replies. Can someone please answer this. on wikipidia it says "Increased ceramide synthesis leads to both leptin resistance and insulin resistance by increasing SOCS-3 expression.[13] Elevated level of ceramide results in the inhibition of insulin signal transduction pathway and the serine phosphorylation of JNK, leading to insulin resistance.[14]" can ceramides in creams be absorbed through skin and cause insulin resistance?

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