Why is my epiduo not working?
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Doctor Answers 1
Loss of efficacy on retinoid
There is a phenomenon that we see with meds used long term called tachyphylaxis. This is basically a diminishing response to continuous or successive doses of a drug. Thus a medication that has worked well for your for some time can rapidly become less effective. It is also possible that with your description of worsening that you are over using your retinoid in terms of amount of product placed on the skin. I would first decrease your dose to the recommended pea sized amount as the forte dosing is stronger than the original Epiduo. If no improvements, I would recommend switching to another retinoid all together.
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