Perlane vs Restylane for Nasolabial Folds?

Perlane and Restylane are supposed to be really similar...what's the difference? Which one is better for nasolabial folds - Perlane or Restylane?

Doctor Answers 2

Perlane for the deeper folds

{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}

Restylane and Perlane are the same hyaluronic acid product made by the same company, Medicis.  Perlane is made of larger particles, and is a bit thicker. They are both very good products.  For deeper folds Perlane is better.  Good luck.

Dr. P


Encino Facial Plastic Surgeon
4.8 out of 5 stars 39 reviews

Nasolabial Folds

{{ voteCount >= 0 ? '+' + (voteCount + 1) : (voteCount + 1) }}

Restylane and Perlane are both hyaluronic acid products with the distinction being that perlane is a larger molecule and is thicker. Depending on the depth of the nasolabial folds, juvederm or radiesse (for more severe cases) would be better options.

Kris M. Reddy, MD, FACS
West Palm Beach Plastic Surgeon
4.5 out of 5 stars 56 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.