Thank you for your question. Large pores are best treated with topical tretinoin cream or gel. A pea sized amount is applied to the entire face nightly or every other night. It is normal and expected to have peeling for the first 1-3 months that will resolve after the 3 month period as long as you are consistent with using the tretinoin. It is okay to use a moisturizer immediately after the tretinoin. If your face stings with the tretinoin wait 30 minutes after washing your face to apply it. It is also possible to use tretinoin every other night or every 3rd night to prevent irritation. Tretinoin will make you more sun sensitive so I recommend a minimum of SPF30 daily and to reapply.