Semaglutide

Ozempic is FDA approved as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes mellitus, whereas Wegovy is FDA approved for chronic weight management as an adjunct to diet and exercise in patients with BMI &gt; 30, or in patients with BMI &gt; 27 and at least 1 weight-associated comorbidity such as hypertension or dyslipidemia. Usual Wegovy dosing for weight loss follows a monthly titration interval, beginning at 0.25mg weekly, then 0.5mg weekly, 1mg weekly, 1.7mg weekly, and a maximum of 2.4mg weekly as tolerated.

Once I get Ozempic, how long does it take to ramp up to the full dose? Anything I need to know about going through that process?

How does Ozempic dosage work for weight loss?

Ozempic is FDA approved as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes mellitus, whereas Wegovy is FDA approved for chronic weight management as an adjunct to diet and exercise in patients with BMI &gt; 30, or in patients with BMI &gt; 27 and at least 1 weight-associated comorbidity such as hypertension or dyslipidemia. Thus if you meet these criteria and are trying to lose weight, you may be a good candidate for Wegovy.

Do I need to be a certain weight or BMI to qualify for Ozempic for weight loss?

Who is good candidate for Ozempic for weight loss?

Ozempic and Wegovy are both branded semaglutide products manufactured by Novo Nordisk. Ozempic is FDA approved as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes mellitus, whereas Wegovy is FDA approved for chronic weight management as an adjunct to diet and exercise in patients with BMI & gt; 30, or in patients with BMI &gt; 27 and at least 1 weight-associated comorbidity such as hypertension or dyslipidemia. Both are taken once weekly as a subcutaneous injection. Ozempic has a maximum dose of 2mg once weekly, Wegovy has a maximum dose of 2.4mg once weekly.

Wegovy was just approved for weight loss but I have read that Ozempic is similar. What are the differences and what will my doctor prescribe for weight loss benefits?

Ozempic vs. Wegovy comparison - What's the difference?

Ozempic face is a term describing changes to skin and underlying support structures that can occur with weight loss, which may result in wrinkles, skin looseness, or volume and unwanted appearance changes. While these negative changes do not necessarily happen to everyone experiencing weight loss with semaglutide, we recommend clinical regular monitoring and early preventive measures to minimize Ozempic face effects.

I have read about "Ozempic face" and how you lose facial fat on Ozempic and it can leave you looking gaunt and thin. Is this true? Should I be worried about this side effect?

"Ozempic face" side effect - Should I be worried?

It should be noted that Ozempic, semaglutide, is approved to improve glycemic control in adults with Type 2 Diabetes mellitus, however weight loss has been seen as an added benefit. Wegovy, also semaglutide, is approved for chronic weight management as an adjunct to diet and exercise in patients meeting criteria. Some patients do gain weight back after stopping semaglutide when used for weight loss, however evidence generally points to better sustainability when treatment is paired with a commitment to diet and lifestyle modifications, physiologic adjustments with longer treatment duration, and allowance of habit psychology to take root for repeatable routines.

I've read in the media about people who have gained the weight back when they stop Ozempic. Is this a real concern, or just a matter of managing weight in other ways?

Will I gain weight back if I stop Ozempic?

To our knowledge there is not currently significant data regarding Ozempic and the metabolism of fat injections or dermal fillers. That said, physiologically there should not be a direct link between Ozempic and dermal fillers.

In 5 weeks I will have some fat injections in my face. Mostly fat but probably also some dermal fillers, depending on what my surgeons suggests for wich area (cheeks, nasolabial, chin, corners of the jawline (not the jowel area)). I am on Ozempic for a while now and I would like to continue to use it after the procedure For 1-2 months. But I need to know if Ozempic will dissolve/metabolize the fat injections/dermal fillers faster or does it have no influence here?

Will Ozempic dissolve/metabolize the fat injections/dermal fillers in my face faster?

Ozempic is approved as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes mellitus. Ozempic is a branded semaglutide product manufactured by Novo Nordisk. Compound semaglutide is produced at specialty pharmacies and thus is not FDA approved for safety, effectiveness, or quality.

I've heard that compound semaglutide isn't FDA approved whereas ozempic is. What is the difference and should I be concerned that one may have more side effects? I'm overweight by about 25 lbs.

What is the difference between compound semaglutide vs ozempic?

It is best to consult your surgeon for a definitive answer, generally we recommend waiting at least 2-4 weeks after liposuction before taking Ozempic or other GLP1 medications.

I’ve had lipo done recently May 2nd to be exact. I’m interested in taking ozempic to help with weight loss. How long after I had lipo do I need to wait before taking ozempic?

How long do I need to wait before taking Ozempic after lipo?

To our knowledge there is not currently significant data regarding semaglutide and lipo fibrosis. That said, weight loss from semaglutide is essentially due to caloric deficit, and thus does not involve the physical inflammation or edema that can sometimes lead to lipo fibrosis.

I wanted too take semaglutide/ozempic for weight loss but am currently suffering from lipo fibrosis 2/3 years post op) Will semaglutide make my fibrosis worse when I lose weight? Or does semaglutide affect lipo fibrosis at all? Just looking too lose fat not to concerned about the fibrosis anymore but I don’t want it to get even worse when I take the semaglutide or become even more pronounced.

Will semaglutide make my lipo fibrosis worse when I lose weight?

As of now, Ozempic is not approved for use in patients with Type 1 diabetes. This medication is primarily used for managing Type 2 diabetes and may not be suitable or effective for Type 1 diabetes management. Always consult with a healthcare professional for appropriate treatment options.

Originally a diabetes medication, can people with Type 1 diabetes use it for weight loss?

Is Ozempic contraindicated for Type 1 diabetes?

Kevin Chang, MD

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