Hello and thank you for your question! When it comes to using trichloroacetic acid (TCA) peels before conception, there isn't strong evidence suggesting it directly affects fertility or early pregnancy. TCA is primarily a superficial-to-medium-depth peel, meaning it doesn’t absorb systemically in significant amounts. However, because skin permeability and sensitivity can change with hormonal fluctuations, reactions may vary. While TCA doesn’t have known teratogenic effects like retinoids or hydroquinone, data on its safety during pregnancy is limited. Once pregnant, skin sensitivity tends to increase, which may lead to heightened irritation or prolonged healing after a peel. If you are unsure, you may want to stick to a lighter peel (10-20%) and either way be sure to have it done by a skilled professional. Best of luck! Genie Alexander, RN BSN for Anna Petropoulos, MD FRCS at Center for Classic Beauty, Boston, MA.