Hands can be rejuvenated with a combination of fillers, fat and lasers. Fillers into this area can improve the appearance of the back of the hands by camouflaging tendons and veins and improving the appearance of her hands and skin by helping lines, wrinkles and folds as well as skin texture due to the long term collagen production. Cannulas prevent bruising and swelling and decrease the pain during injection. Radiesse lasts up to one year, but unlike other fillers, it provides long-term collagen production. This means that even after the filler has dissolved, the area it was injected to is still improved because of the collagen that built.The Fraxel Laser can be used to completely rejuvenate and tighten the skin. After a few days, the skin on her hands will be completely fresh with rebuilt collagen, reduced of any wrinkles and lines, and be much tighter.I recommend getting a formal evaluation with a Cosmetic Dermatologist. Best, Dr. Emer