What medication best prevents post-operative vomiting?

In my experience it's best to PREVENT post-op vomiting in patients with a combination of medications used DURING surgery.  For the small subset of patients that we do not succeed in doing so, we use Zofran ODT commonly with good results. 

Many factors may result in nausea or vomiting after surgery. Zofran is the best option for trying to prevent this after surgery. 

Vomiting  Can occur from a variety of issues such as swallowing blood down the back of throat from the rhinoplasty procedure, the anesthesia side effects, or narcotic medications.  There is no guarantee prevention, just reduction chance for it to occur.  There are multiple medications  which can be prescribed by your surgeon and/or anesthesiologist which include scopolamine patch, Zofran, and some intravenous medications which can also help as well.