Yes, a frozen section biopsy can be done prior to Mohs surgery. I tend to limit this practice to very few situations though. For example, if there is a suspicious lesion immediately adjacent to where I am working, I want to know what it is, as it could affect my closure.
The potential negatives include:
1. A frozen section biopsy does not provide the same cellular detail and can have artifact that a permanent section biopsy does not have.
2. There may be a bias that develops when reading a biopsy right before surgery...of course the incentive is to read this out as a BCC (when it may be something like a trichoepithelioma instead). If the biopsy is read by another dermatopathologist, this potential bias is eliminated.
3. Sometimes it is difficult to make a diagnosis and you may require immunohistochemistry studies or need a second opinion. Doing the frozen section biopsy right before Mohs makes it very difficult to do this.
4. What if your biopsy is negative right before Mohs? Then the doctor has blocked a large amount of time on his schedule for your potential Mohs surgery which is cancelled. This is not fair to other patients who are waiting for this procedure and creates a scheduling nightmare.
So there are many negatives with doing this approach of biopsies immediately before Mohs.