It is very unlikely that a patient would have zero response to Dysport when injected properly in the proper dosage. Some patients require more units than others, but this dosing varies from one person to the next. Dysport injections usually start to take effect 4-5 days after treatment, and will reach their maximum effect by around days 7-10 after injection. I always tell my patients that the lines will not disappear immediately, and in some cases, may never completely disappear if the lines are very deep initially. In almost all cases, the lines will soften over time as the skin remodels while it is no longer being repeatedly creased by dynamic muscle movement. I always recommend speaking to the doctor who performed your injections about any questions or concerns. All the best,