You don't have to decide what treatment is best on your own. When you consult with a board-certified dermatologist, he or she will evaluate your lips and make recommendations based on your desires and needs. Botox and Restylane have very different mechanisms of action. Botox relaxes muscles. Restylane adds volume to lips and skin. If your crooked smile is caused by a muscular imbalance, then Botox may help. If it's an anatomic asymmetry, then Restylane would be the best solution. If you are trying to estimate the amount of product you need because you are concerned about cost, then this too can be addressed in your consultation. Please see a board-certified dermatologist to find out all of your options so you can make an informed decision.