Which Restylane product lasts the longest in the nasolabial folds?

I agree that there's no way to get an appropriate answer to this, but I can tell your that Refyne and Defyne look way more natural than the traditional Restylane products. How long they lasts is too variable depending on your age and ability to metabolize the product differently from other folks.Have a formal consultation with an experienced injector for best results!Dr. ALDO 

Hi @PeaceL0veBeauty! Restylane Defyne is a great option for nasolabial folds. The longevity of a dermal filler depends on your age and how fast you metabolize the product. The results typically last for 6-12 months. Best of luck, Dr. Nima!

Photos would have been extremely helpful. Not uncommonly new patients come to me asking me to treat  this or that particular line or fold, such as smile lines or marionette lines, mistakenly thinking that doing so would solve their problems and rejuvenate their faces. Over three decades ago, when we knew much less about what actually goes on within the aging face, we did just that, i.e. simply chased after the individual lines. But, more often than not, after doing so, we ended up with patients who were unhappy with their results; they didn't have the lines or folds, but they really didn't look younger. And sometimes, pushing in more filler to further flatten, say the smile lines, created what has become known as the "simian facies," i.e. the smile-line-less look of a chimpanzee. Facial sagging, with the appearance of smile lines, marionette lines, jowls along the jawline and even sacs under the eyes, actually stems from significant loss of volume within the fat pads of the upper and to some extent the mid cheeks (not from weight loss, but often unmasked by significant weight loss, as likely is the case here). Restoring the volume in the cheeks with a volumizing filler is therefore the more appropriate measure for rejuvenating the face. One wouldn't consider painting the rooms of a house first before putting in its foundation. Yet, that is what most patients mistakenly request and most inexperienced, novice injectors and medspas do in cases such as yours. Today, experienced aesthetic physicians perform facial sculpting and contouring with fillers, rather than simply filling lines. To illustrate this very important point, just pull upwards and backward in the cheekbone region and you will likely note a tremendous, secondary diminution in your smile lines. This is so, as was already pointed out, since cheek volume loss is largely responsible for the development of these folds. In my Upper East Side Manhattan practice, I would choose Voluma XC for the cheeks and in my Israel satellite facility, where a far greater number of agency approved volumiziing fillers are available, I would opt for Stylage XXL for this purpose. Additionally, were one to treat the smile lines directly, owing to the fact that this area is subject to so much movement, the results typically would be expectd to last only about a year. By contrast, when treating the cheeks, an area not subject to as much mechanical stress, results may last up to two years particularly with the more robust fillers mentioned above. For more information on the above, you may wish to perform a search under The Nonsurgical 3D Vectoring Facelift in the archives of RealSelf.com.  You would do well to consult with a board certified aesthetic physician to discuss these issues, and be certain to ask to see his/her before and after photos before agreeing to proceed. Best of luck. 

If you're seeking a filler in the "Restylane" portfolio - I have been very impressed with Refyne in the nasolabial folds and Defyne in the malar pads (cheeks).   Restylane Lyft is also a good choice.  Duration is up to 12 months but depends on the patient.   There is a significant range of filler choices and it's very important to find an experienced provider who understands which fillers are most effective in each area.  It's very similar to an artist with different brushes and a variety of mediums.  We use products from both Allergan (Juvederm portfolio), Galderma (Restylane portfolio, Sculptra) and Merz (Radiesse).  Each product has it's strengths and weaknesses and they must be tailored to each person's unique anatomy.

Restylane, Radiesse and Juvederm are all good for nasolabial folds. Keep in mind, a combination approach will give the most improvement for nasolabial folds. I recommend fillers for the folds themselves but also lifting around the mouth and cheeks to build underlying anatomical support. In our practice we combine sculptra with other fillers "layered" on top and lasers, rf treatments, J Plasma and peels to get the most conservative natural look. Please see a facial sculpting expert. Best, Dr. Emer

Thank you for your question. It is difficult to give advice without examining you in person or seeing a photo. However, the longevity of fillers will depend on many factors such as how your body metabolizes the product. Typically Restylane lasts 6-12 months. I recommend having a consultation with an expert injector to determine the best treatment plan for you. Best of Luck!

Thank you for your question.  Restylane is a great option for your nasolabial folds. Restylane is derived from hyaluronic acid which is a natural moisturizing component found in your body. It is typically used for areas of the face that experience volume loss over time and age. The longevity of a dermal filler depends on your age and ability to metabolize the product. For more information, please make sure you get a in person consultation from a board-certified dermatologist. 

Hello,The answer to this question has a lot more to do with how the injection is done rather than which version of Restylane (or other brand) is used.  How the injection is done is determined by what type of correction you are doing and whether the injector is skilled. First, a little background.  There are two considerations here.  1) how long does the actual Restylane last.  2) How long does the visible improvement last.  These are not the same thing.  Restylane can be injected into the skin itself (the dermis), or into the tissues under the skin.  Injections into the dermis are meant to correct damage within the dermis, namely, creases.  In contrast, fillers injected under the skin are meant to change the contour of the skin by pushing it out, but not change the skin itself.  These are very different things and have very different longevities.  A good analogy is to take a piece of paper and compare two situations.  First hold it up on each end and let it sag, now set it back down.  The paper itself is undamaged and goes back to nice and flat.  The table under the paper is pushing the paper up, much like filler injected under your skin.  Now pick the paper up and crease it.  When you put it back down, the paper still has a crease, because the actual paper fibers are damaged and lifting from underneath does not fix that.  There is a very specific way of injecting filler into the dermis such that the skin actually REPAIRS ITSELF.  This is a big deal.  Restylane injected into the dermis using specific techniques stimulates the cell type called fibroblast to make new collagen.  This in short "re-weaves" your skin and actually fixes the crease.  Even after the Restylane has dissolved, the crease continues to be fixed.  The improvement usually lasts years.  A typical smile line correction for me consistes of 2cc's at the first treatment, 1cc 9 months later, then 1cc every couple years.  I usually use standard Restylane for this, but you would get a similar result with Defyne with a slightly smoother feeling result during the first month or so.When injecting under the skin, there is no fibroblast reaction.  As the Restylane dissolves, the result completely goes away.  When correcting a "sagging" type problem rather than a crease type problem, the filling needs to be done much more often.  Perhaps every 6 months.  This depends on the person and the part of the face.  Which "flavor" of Restylane you use here has a bigger impact on your visible result since they dissolve at different speeds.  Using the pricier and smoother Defyne isn't really going to make a difference if injecting under thick skin.  Generally I use Restylane Lyft in this situation for its longevitiy.  Also I use Voluma for this, again, for its longevity.Be aware, that if you are correcting smile "lines" that aren't actually creases in the skin but just a smooth dip in the skin, then collagen re-weaving is of no benefit and the result dissolves with the product.  If you are treating the more common true creases, when done well, the result is much more permanent as the improvement perists well after the Restylane has dissolved.Best Regards,Dr. AAustin, Texas

This is a hard question to answer because the longevity of fillers varies based on the sites treated and a person's own metabolic activity. Typically, I tell my patients that Restylane family fillers in the nasolabial folds last 9-12 months. My preferred fillers for the laugh lines are Restylane Refyne and Restylane Defyne because they are flexible and integrate nicely into the skin giving a very natural looking result.

Hi,There is no good answer to this question unfortunately. Different fillers say they last 6 months or even up to a year. However, everybody is different and their body will breakdown and absorb fillers differently. Usually, when you see a doctor they will give you their recommendation and if one doesn't last long enough they will try a different one the second time. Best wishes!