Restylane Defyne or Refyne for marionette lines?

Great question! The Rheological (Physical) properties of all fillers on the market has been extensively studied.  When injecting fillers around the mouth, as you can imagine, it is very important that the filler used is very elastic due to the extreme motion that occurs in this region of the face compared to, say, the cheek.  The most elastic filler product on the market is Restylane Refyne, and not far behind it is Restylane Defyne.  The choice of which one to use depends on the depth and degree of volume loss. They are both wonderful options due to their flexibility.  Perlane is now called Restylane Lyft as it was remarketed and launched with the latter name.  It is the stiffest product with the least flexibility of any filler on the market, and it would be a poor choice used around the mouth, but is excellent for midface/cheek projection.  Please see your trusted provider for an in-person consultation so that he or she can choose the best product for your goals. 
Hope this is helpful to you!

Thank you for the great question.
Both belong to the Restylane family of hylaronic acid injectable dermal fillers.  Restylane Refyne was approved for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds.  Restylane Defyne is approved for the correction of moderate to severe deep facial facial wrinkles and folds. 
Both of these gel fillers is made with a flexible hyaluronic acid filler which uses XpresHAn Technology – creating gels that offer a wide range of flexibility and support.  This gel moves and molds with your natural movement and then returns to its natural shape – so it is perfect for the areas of the face where there is a lot of movement such as the nasolabial folds, marionette lines and laugh lines around the mouth. They provide excellent results for animated areas of the face where we want to maintain natural movements and expressions.
Both of these fillers last up to 12 months compared to regular Restylane which lasts approximately 6-9 months.  
As always, an in-person consultation with a board certified dermatologist with cosmetic training is the best way to assess your needs and provide medical advice.