How long does it take for hyaluronidase to completely dissolve Restylane Defyne?

Refyne and Defyne are fillers that are rheologically designed to compete with the Allergen Hylacross products in the Juvederm family.  That is to say they are "smoother" like the juvederm products.  Contrast this to the high G prime, low tan delta fillers like Restylane and Lift.  Injectors have a tough time with these type of fillers  because they need to be sculpted into shape once placed.  Refyne and Defyne are more runny or "smoother."  What they are not is they are not more "fibrous."  It is unclear if these rheological differences contribute to meaningful differences in longevity.  Hyaluronidase breaks down all of these products.  The issue is dose of hyaluronidase.  Most injectors managing complications due to these fillers do not use sufficient quantities of enzyme to get the job done.  With a sufficiently high dose of enzyme, the filler will be removed with a single treatment.  Generally the enzyme acts immediately but the full effect of the enzymatic breakdown takes a couple of days, possibly more if there has been trauma.

Hi GirlofGratitude,

I am Sarah, a medical assistant at Aesthetic Skin MD with Dr. Anil Shah in Chicago! It takes hyaluronidase 24 to 48 hours to start working and about a week to fully dissolve the filler, so I would wait a week or two before seeing a provider for more hyaluronidase.

Thank you for sharing your question.  All of the HA fillers can be dissolved with appropriate dosing of hyaluronidase with dissolving taking place over a matter of hours.  Be sure to see an ASPS board certified plastic surgeon in consultation for treatment.

Usually it is rather quick result from hyaluronidaze but sometimes resultant swelling/bruising can take a few weeks to completely subside. It also depends on how much hyaluronidaze in injected and what type of filler is present and also on the technique used.

The full effect of hyaluronidase is completed at 3 days. It might take more than one treatment to dissolve. It depends on the amount of product you want to dissolve and the amount of hyaluronidase used.

Thank you for your question. The full effect of hyaluronidase on HA fillers such is Restylane Defyne is usually seen within a matter of hours. Due to the structure of Restylane Defyne and Refyne it is a bit more difficult to fully dissolve the product with a single treatment. I would recommend following up a few days after your initial hyaluronidase if you feel more product remains that you would like to have dissolved.
I hope this was helpful - Dr. Moore.