What is the difference between non cross-linked and cross-linked hyaluronic acid

Question

what is the difference between non cross-linked and cross-linked hyaluronic acid with regard to efficacy, way of injection , side effects. Thanks

Razan Kadry, MD · Answer

great question! Non-cross linked hyaluronic acid 'flows' in the dermis which plumps up the skin and softens lines , but when injected, it does not 'stay put' at the site of injection. Whereas with cross-linked hyaluronic acid, it has a chemical preservative called bdde that allows for the hyaluronic acid to fill the area and 'stay in the place' of injection. One example of a filler is juvederm voluma.

David P. Melamed, MD · Answer

Hyaluronic acid (HA) is a naturally occurring compound in your skin.  In the simplest terms it is a like a sugar molecule. Scientists have learn to chemically manufacture HA using bacterial fermentation.  The HA in its raw form (non-cross linked) can breakdown easily. In order to make the HA more durable scientists are able to link the HA molecules to one another.  This linking process makes the HA more durable.  More cross-linking makes the HA molecules firmer in consistency, more water absorbent when injected, and longer lasting.An experienced clinician will choose the HA with right amount of cross-linking to meet your specific needs, based on the area/s requiring treatment.

What is the difference between non cross-linked and cross-linked hyaluronic acid

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What is the difference between non cross-linked and cross-linked hyaluronic acid

Answers (2)

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Everything you need to know about Dermal Fillers

Our mission is to create a world where every investment in modern beauty is Worth It.