Fixing uneven smile lines caused by uneven facial muscles? (Photo)

Is there anything that can be done to remedy an asymmetrical smile that is the result of uneven facial muscles/fat distribution? Would botox/fillers help to make the smile more even? I'm looking for 1. improvement in the creased corner of my mouth 2. improvement in the symmetry of the lines originating at the nose. I have attached four photos below, 2 from a heavier weight and 2 from when I weighed about 50lbs less to show how the uneven smile pull still shows regardless of fat distribution.