Jeuveau - will it work if Botox has stopped working on me?

Jeuveau is a type A neuromoduoator, like Botox, with an identical molecular weight to Botox.  Dysport and Xeomin are also type A neuromodulators.  Theoretically, if one didn’t work none of them would work.  It is extremely rare for someone to get desensitized to any of these products, where they would stop working and usually only with frequent treatments using very high doses for medical uses.  Also, if you were desensitized it would not work at all.  If it seems to not be working as well it could be for one of the following reasons:1. You went to a new injector who is injecting you in a different pattern or with lower doses.2. You did not get Botox but instead a weaker product like Xeomin or Dysport.3. You are “recruiting” other parts of the muscles or surrounding muscles around the treated areas which are now moving because you can’t move the areas that were injected.  This is your brain trying to find a work-around.If your injector is experienced and customizes your treatments he or she should be able to change your dose and/or injection sites to fix this problem, with either Botox or Jeuveau.

Hi and thank you for your question! Botox, Jeuveau, Xeomin and Dysport are all from the same family of medications with similar active agent derived from botulinum toxin which works to relax muscles. Some patients might gradually develop some "resistance" to these medications after years of use and in such cases, switching from one type to another (e.g. Botox to Jeuveau as you described) can be considered and it might help in some patients. I hope it helps and good luck!

Thank you for sharing your excellent question. Although for the majority of patients all neuromodulators will have the same efficacy and duration of results there is a small subset that simply do better with one product over the others.  Because each of the neuromodulators work in slightly different ways you can try Jeuveau to see if you are able to maintain a more appropriate duration of results. Hope this helps.

I would try xeomin over Jeuveau but both can be tried if you have "lost" function of botox.  Best, Dr. Emer.

Thanks for your question. It is not really possible to make a completely accurate prediction about how long Jeuveau will last for you, but it is certainly worth a try! I have been using Jeuveau for my patients for two years now, and am very happy with it. It seems to last about the same amount of time as Botox, but since it has a few slightly different properties, it might last longer for you. Find a trusted provider you like, and give it a try!

Hello and thank you for your question! There is no way to know if Jeuveau will work for you without trying it. There could be several reasons why Botox is only lasting a few weeks. Perhaps you have a new injector that is not treating appropriately, are getting less units than usual, are requiring more units, or there was a problem with the way the vial was mixed or stored. It is also possible but rare to form antibodies to Botox, making it less effective. We have had patients in our practice that tried Jeuveau after not seeing the results they desired with Botox and they have been happy. I would discuss your concerns with your injector and see what they think. Best of luck!

Thank you for your question. There is no precise way to know whether Jeuveau will avoid the issues you have had Botox Cosmetic in terms of duration other than to give it a try. You may require a higher than average dose of the neurotoxin as this is often seen in patients as they get older. Due to the way Jeuveau is manufactured and packaged patients do not form antibodies to the molecule. This is rare but the principal cause of Botox losing its effectiveness. The question would be whether you have formed these antibodies and whether their is cross reactivity with the Jeuveau molecule. There is not a lab test that is going to give you this information so I would recommend giving it a try.I hope this was helpful - Dr. Moore.

Jeuveau is similar to Botox and other neuromodulators.  It's difficult to say if you will have better luck with Jeuveau longevity versus Botox.  Discuss your history with your injector.  Be sure to include the number of units you have had injected in the past as well.

There are very few differences between Jeuveau and Botox. Both are very similar sized molecules with very similar action. Dysport and Xeomin have characteristics  different enough that I find patients may prefer or tolerate one over another. I have many patients whom I switch between Botox, Dysport, and xeomin, but I have not seen enough of a difference with Jeuveau to really form an opinion. Since it is new on the market, it may be worth a try, but dysport would probably be my next option for you. Best of luck

Thank you for your question Gym_mom_951. I understand your concern. Jeuveau is a purified protein used to address wrinkles associated with facial expression. When injected into the skin Jeuveau will relax the muscles and smoothen out the overlying wrinkles. The most common areas of treatment are in the upper face. These include the horizontal lines seen on the upper forehead when one raises the brows, the vertical lines seen between the brows when one frowns (frown lines), and the crow's feet seen around the eyes when one smiles.
In rare cases, some people are resistant to a certain neuromodulator such as Botox. In this case the treatment can be repeated using a different neuromodulator such as Jeuveau, Dysport, or Xeomin.Since Jeuveau is almost identical to Botox in terms of the chemical composition, it may or may not work for those resistant to Botox. We will have to see. If I had a patient with the concern described her I would say it would be worth a shot to try Jeuveau.With any injection, there are risks such as pain, bleeding, bruising, redness, swelling, tenderness, and infection. We take special precautions to minimize these risks such as using a painless technique. We also treat bruises with a laser as early as the next day. Bruises usually resolve within two weeks if untreated. After a laser treatment bruises usually resolve in 1-3 days, but may still take two weeks for full resolution. In addition to these risks, with Jeuveau there is also a risk that the product spreads or diffuses to nearby structures. Spread to nearby muscles can lead to side effects such as the temporary appearance of droopy eyelids or a temporary asymmetric smile.

After a Jeuveau treatment, I recommend that my patients avoid heat exposure, alcohol consumption, and strenuous exercise for 24 hours and not lie down flat for four hours. This is because all of these activities may possibly lead to the movement of the product and consequent side effects such as droopy eyelids. Although there have been no definitive studies shown that these actually occur and some physicians do not provide such aftercare instructions, in the absence of data I err on the side of caution and recommend that my patients avoid such activities.

Please consult with a doctor for specific recommendations. Good luck!