Jeuveau (prabotulinumtoxinA-xvfs) is an FDA-approved injectable treatment that temporarily smooths moderate to severe glabellar lines, the frown lines between the eyebrows also known as “elevens.” It's also used off-label to treat lateral brow lines, bunny lines (from crinkling the nose), chin wrinkles, crow’s feet, a gummy smile, lip lines, and neck bands, according to Dr. Sheryl Clark, a board-certified dermatologist in New York City.
Sometimes marketed as Newtox, this “purified” form of botulinum toxin A has a molecular weight similar to Botox, with similar risks and side effects.Â
When injected, Jeuveau relaxes (and at higher doses, paralyzes) the facial muscles of expression. By keeping muscles from making repeated movements, it helps prevent fine lines from forming and softens facial wrinkles that have already made their mark.Â
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Jeuveau and Botox are both forms of botulinum toxin type A. However, some doctors and reviewers on RealSelf have noted a few differences—one being that Jeuveau seems to kick in a few days earlier.
What’s more, Dr. Clark adds, “Patients have shared the impression that it comes on and wears off very naturally.”
Related: Jeuveau vs. Botox: I Tried Both, and Here's My Honest Review
Pros
Cons
Jeuveau costs between $8 and $20 per unit. Your total treatment price will depend on:
Jeuveau is considered an elective cosmetic treatment, so insurance doesn’t cover it, but many practices offer monthly payment plans.
The Jeuveau photos in our gallery have been shared by the provider who performed the procedure, with the patient's consent.
Jeuveau injections are best administered in a doctor’s office by a physician, PA, or highly trained nurse injector.Â
There isn’t any downtime after treatment, but you may have some localized tenderness, swelling, bleeding, or bruising associated with the injection.Â
Follow your injector's recommendations for aftercare. Many advise against these activities for up to 24 hours post-treatment:
Your muscles will start to relax within 2 days, but it can take a week or longer to see full results. (That’s a bit faster than Botox, which can take up to 2 weeks to fully take effect.)
It’s not uncommon for patients to return to their doctors 10 days post-treatment to “see the effects and tweak the treatment plan to optimize future treatments,” says Dr. Clark. Occasionally, they’ll add units to perfect the results.Â
Related: The Treatments and Ingredients Actually Proven to Reduce Wrinkles
Jeuveau lasts 4 months, on average, according to clinical trials, while Botox lasts 3 to 4 months.Â
Longevity can vary by patient and dose. “The higher the dose, the longer it lasts—up to a point,” notes Dr. Clark.
“Botox and the other neurotoxins may become less effective over time in some patients,” says Dr. Steven Goldman, a plastic surgeon in Beachwood, Ohio. “One theory is that antibodies build up, neutralizing the Botox before it gets to the nerve ending.”Â
Doctors on RealSelf say that the only way to know if Jeuveau will work for you as a Botox alternative is to try it. Each of the neuromodulators has slight differences in its chemical makeup, so it’s possible Jeuveau will work if your body has stopped responding to others. Â
In Dr. Goldman’s experience, however, “switching to a different brand of botulinum toxin usually doesn't make this problem go away. In general, patients will require higher doses [at greater expense]—and the toxin effect won't last as long, even at higher doses. Nonetheless, trying Jeuveau is reasonable.”
As with any injection, potential side effects include pain, bleeding, bruising, redness, swelling, tenderness, and infection.Â
In Jeuveau clinical trials, some patients also reported headaches, eyelid drooping, upper respiratory infection, and an increased white blood cell count were all reported.
Rarely, patients experience allergic reactions marked by itching, rash, welts, wheezing, and trouble breathing. However, this treatment is safe for those who have an egg allergy or a dairy allergy. The protein it contains is human serum albumin, derived from human plasma, which is different from the albumen protein found in egg whites and milk.
Botox Cosmetic is the most popular form of botulinum type A. It has a wide range of FDA-approved cosmetic uses, including softening frown lines, forehead wrinkles, neck bands, smile lines, and smoker’s lines. It’s also medically approved for a variety of medical indications, including excessive sweating and migraines.
Dysport is another form of botulinum toxin. The injection process and longevity are similar to those of its competitors, but Dysport reportedly kicks in a bit sooner than Botox. Upon injection, Dysport has been known to spread more than the other substances—which, in skilled hands, can mean a more natural-looking result and, in less-practiced hands, could lead to an increased chance of drooping eyelids or brows.Â
Xeomin is another popular alternative for reducing the appearance of lines and wrinkles. Xeomin contains only the active core molecule of botulinum toxin A, minus any complexing proteins. For this reason, Xeomin proponents believe the body is less likely to develop a resistance to it.Â
Daxxify, the newest neuromodulator on the U.S. market, contains a novel peptide purported to help it to last longer (up to six months, in most cases, according to company trials). The peptide also eliminates the need for human serum albumin, a stabilizer found in other neuromodulators. Since the product’s launch, however, many reviewers on RealSelf have complained that Daxxify doesn’t live up to its longer-lasting claims. Such dissatisfaction has contributed to the treatment’s unusually low Worth It Rating.
Related: What’s the Difference Between Botox, Dysport, Xeomin, and Jeuveau?
If you’re wary of toxins or needles, there are other effective treatment options for fine lines and wrinkles, including fillers, lasers, and ultrasound or radiofrequency energy treatments. A board-certified dermatologist or plastic surgeon can recommend the best one for your specific concerns and goals.Â
Updated December 1, 2023