Dear Flossg01, Absolutely, you bring up an important point that's often on many patients' minds: post-operative care and comfort. After a procedure like a tummy tuck, Lipo 360, or a Brazilian Butt Lift (BBL), it's normal to experience some discomfort or reactions as your body adjusts and heals. This can sometimes lead to itchiness, swelling, or difficulty sleeping. Benadryl, or diphenhydramine, is an over-the-counter antihistamine often used to alleviate allergic reactions, reduce itching, and help with sleep. In general, it is safe to use after these kinds of procedures. However, like with any medication, discussing this with your surgeon or their team is always a good idea before taking it. They will be able to provide the best advice tailored to your specific circumstances. One thing to keep in mind is that Benadryl can cause drowsiness. This is typically a desirable side effect for those having difficulty sleeping after surgery. However, it's crucial to consider this if you need to be alert or are taking other medications that might also cause drowsiness. Always read the package instructions and follow the recommended dosage. Thank you for asking this question. It's always a pleasure to help clarify these aspects of post-operative care. Good luck with your procedure and the recovery process. I'm sure you'll do great! Sincerely, Dr. Katzen.