Filler substances -- such as Restylane, Juvaderm, Radiesse -- are FDA approved for use in the US to correct facial wrinkles and to add volume to the fave. However, they have not been given an specific indication by the FDA for a "non-surgical nose job" -- thus, they are being used in an "off-label" fashion for this purpose.The deformity of the nose will dictate how much of the injectable substance is required to achieve the desired result. While injectable fillers may be appropriate for treating localized deformities such as depressions or a low bridge, large volumes are required for an substantial change in nasal shape.Many surgeons are beginning to see patients who come to their practice for revision surgery because they are displeased with the results of injectable fillers. Most of the products that have been on the market for the last several years are temporary. However, newer, longer-lasting fillers have become available. Some of these are permanent. This poses a problem when the result does not meet the patient's expectations. The large volumes of these substances are changing the way the natural tissues appear, which can make revision surgery more difficult, and in some cases, impossible.Over time, these fillers have been noted to cause skin changes, such as redness and even skin necrosis, in some patients if they are injected too close to the surface of the skin. They may also give the nose a lumpy appearance.