It is the procedure itself- microneedling- that gives you the best results. Although you have to be careful to which products you use topically, it does not really matter what you use. In my practice we use a HA serum and Growth Factor and we see great results. But, I think that we would still see great results even if we didn't offer the growth factor.
Yes, it can. The additives enhance results but are not needed for microneedling. You you chose to go without growth factors, then you may not have as great results that you would with them. Good luck!