Hi audrao, I have extensive experience in Botox and have used it for some medical conditions but I have never used it to treat psoriasis. Psoriasis, an autoimmune disease is an inflammatory response and a documented study showed that Botox injections did help improve conditions in the axilla and groin areas. But as far as I know, it hasn't progressed much beyond the "study" stage.There are better ways to manage psoriasis, most of them begin with lifestyle changes. All the best, Justin Harper, M.D.