Thank you for your question and for submitting your photo. It's difficult to make exact recommendations without assessing you in-person. However, based on your photos, your would likely benefit from a combination approach. Often times, sagging and loose skin on the lower face and jawline are related to volume loss in the mid and upper face - I often recommend starting with fillers on the cheekbones, to help lift and contour the cheeks and jawline. I find that Voluma works particularly well in this area, and is one of the longest-lasting hyaluronic acid fillers on the market. You would also likely benefit from fillers directly in the folds below the corners of your mouth. In my experience, both Refyne and Defyne are thinner, more runny fillers, and likely would not provide enough structure to lift the corners of your mouth. I would recommend a more robust product like regular Restylane or Juvederm Ultra Plus in this area. You may also consider laser skin resurfacing treatments to help stimulate collagen and improve overall skin texture. I would recommend scheduling a consultation with a cosmetic dermatologist to discuss the best treatment options for you. Best of luck!