Botox to the palms of the hands and / or soles of the feet is tolerable but in my experience more painful than Botox to the face. There are measures that your provider may take to reduce your discomfort with topical anesthesia, ice pack, etc but most people are able to tolerate the treatment without problem. It is also very safe as long as you are going to an experienced injector. Not everyone is a good candidate for this treatment so please see a Board Certified or Board Eligible Plastic Surgeon to evaluate if you may benefit. Good luck! This content is for educational and informational purposes only. It is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare professional. You should always seek the advice of your physician or healthcare professional for any questions you have about your own medical condition.