While both Juvederm Voluma and Juvederm Ultra & Ultra Plus are composed of hyaluronic acid – a natural moisturizing component of our skin – each has a slightly different formulation. They both have cross-linked molecules that help to build a matrix to support the skin and engender new production of collagen, but the Voluma molecules are more tightly cross-linked and the formulation is thicker. Therefore, it creates and sustains more volume, lasting up to 2 years. Juvederm is thinner, only lasts about a year, and can fill in wrinkles, lips and nasolabial folds, but cannot create significant volume in the midface. Consulting a board-certified dermatologist will help you decide which – or both – of these highly effective HA volumizers is right for you.