Hello and thamk you for your question! For hand rejuvenation, dermal fillers are an excellent option to address aging signs, visible veins, and tendons. The hands naturally lose volume over time, leading to a thinner appearance where veins and tendons become more prominent. Fillers work by restoring volume, providing a smoother, more youthful look. Hyaluronic Acid fillers, like Juvederm or Versa, are often used because they’re biocompatible, relatively easy to reverse, and provide immediate results. These fillers can add volume to plump up the skin, reducing the appearance of veins and tendons. They typically last about 6-12 months in the hands, depending on factors like metabolism and product choice. Radiesse is also a common choice for hand rejuvenation. Unlike HA fillers, Radiesse stimulates collagen production, making it especially effective for hands where skin thickness is an issue. Its effects last longer (often around 12-18 months), and it can provide a smooth, natural feel and look. I hope this helps! Best of luck. Genie Alexander, RN BSN for Anna Petropoulos, MD FRCS at Center for Classic Beauty, Danvers & Boston, MA.