Hello and thank you for your question! Hand rejuvenation is so important, and often overlooked. In our practice, a combination approach targeting skin quality, volume loss, and overall texture is highly effective. 1. DefenAge 10 Luxe Hand & Body Cream Why It Works: This cream is formulated with Defensins, which stimulate skin's natural repair processes and improve texture, hydration, and brightness. This is the only product on the market that actually creates *new* skin. It’s excellent for addressing crepey skin and promoting a more youthful appearance over time. 2. RF Microneedling Why It Works: RF microneedling combines radiofrequency energy with microneedling to stimulate collagen production, tighten skin, and improve texture. It’s ideal for addressing crepiness, fine lines, and thinning skin on the hands. Treatment Plan: Typically, 3-4 sessions spaced 4-6 weeks apart provide noticeable improvements. Maintenance sessions can be done annually. 3. Soft Dermal Fillers Soft fillers can restore lost volume, smooth out visible veins and tendons, and improve skin hydration. Options include: Versa (Hyaluronic Acid-Based Filler): Adds subtle volume to the hands, minimizing the appearance of veins and tendons. Typically lasts 6-9 months in this area. Skinvive by Juvederm: Focuses on improving skin hydration, elasticity, and glow without significant volume. Ideal for enhancing skin quality. RHA Redensity: Provides natural hydration and volume with a smooth, skin-like finish. Great for hands requiring a delicate approach. Treatment Plan: Results are visible immediately, with peak results after 2-4 weeks. Expect touch-ups every 9-12 months for maintenance. Combined Approach: Step 1: Start with DefenAge Hand & Body Cream to improve skin texture and hydration over time. Step 2: Introduce RF microneedling to address crepiness and tighten skin. Step 3: Use soft fillers to restore volume and enhance overall hand rejuvenation. This holistic approach addresses both skin quality and volume loss for a comprehensive rejuvenation plan. A consultation with an experienced injector can determine the best filler option based on specific anatomy and goals. Best of luck! Genie Alexander, RN BSN for Anna Petropoulos, MD FRCS at Center for Classic Beauty, Boston, MA