Hello tunia135, Duration of action regarding Hyaluronic Acid (HA) dermal fillers is a very common question for us in a clinical setting. Over the past 14 years, I have had the opportunity to use all the HA fillers that we have available to us on the Canadian market. There are several factors which will influence how long the filling effect of any HA filler persists. Probably the most significant factor, is the choice of HA filler in regards to thickness. Now, in saying thickness, I am over simplifying a much talked about property of HA dermal fillers. That being said, from a patients perspective, the various dermal filler companies will produce a family of HA fillers, each with unique characteristics, one of those characteristics is what we can call thickness. Generally speaking, the thicker products will last longer than the thinner products and medium products will last somewhere in between. The duration will range from 4 -6 months for the thin products, 6-8 for the medium ones and 12-18 months for the thicker products. Also important to understand is how, or why we choose a particular thickness of HA filler. Again, to simplify and generalize, the thicker products will provide the most lifting, or filling effect, whereas the thinnest HA filler will provide minimal to no lift at all. Thicker products are more likely to be used in the cheeks, temples, chin and jaw. Medium products in the forehead, anterior cheeks and lips. Finally the thinnest of HA fillers are used to treat more superficial lines and wrinkles. Finally, to answer your question, the most important choice you will make is in choosing a physician who has the experience and artistry to address your concerns. The physician, through their understanding of the various HA fillers available will choose ones that will address your issues, with a view to the ongoing weight loss that you are experiencing. Having a physician who appreciates that each HA filler has its own personality will ensure that your results are optimal - balanced and natural. I always say, "You can never use too little filler". The worst that can happen is that you have to add a little bit more. One of the best properties of HA fillers is that they are reversible. All physicians will have a supply of an enzyme called hyaluronidase in their offices. Hyaluronidase will very rapidly and safely breakdown HA fillers. So if you are ever at the point, where for some reason, you, or your physician is unhappy with the effect of your HA filler, they have the ability to reduce, or completely remove it. I hope that explanation helps. Congratulations on your ongoing weight loss efforts!