What can I do about the vertical wrinkle down the center of my philtrum? (Photo)

Filler can temporarily improve the area. However, for a more permanent solution I recommend an Elelyft lip lift along with fat transfer. Best of luck.Gary Linkov, MDLip SpecialistManhattan

That wrinkle is related to the contraction of the orbicularis muscle. A small amount of Botox or Dysport in that one area could be extremely helpful. There are superficial filler like Restylane Silk or Belotero that could be injected directly in that wrinkle and improve the looks of it. 

Thank you for your picture and questions. An in-person exam would be very helpful. It is possible that a lip lift procedure would be exactly what you need. Make sure you see a plastic surgeon who is board certified by the American Board of Plastic Surgery.Good luck!Dallas R. Buchanan, MD, FACSOwner & Board-Certified Plastic SurgeonVIVIFY plastic surgery

Certainly, fillers can are an option.  The other alternative may be a lip lift.  A lip lift does 4 things: shortens the distance between your nose and upper lip, increase the mucosa of the upper lip, increases the incisor show and pulls up the corners.  Unfortunately, you have not provided photographs of your entire lip.  It may be possible that the lip lift will also spread and improve the crease that you describe.  Best Wishes,Gary Horndeski, M.D.

Thank you for your question.Fillers such as Restylane Silk, Belotero, or Juvederm can work well to treat lines around the mouth, but the best first option is laser resurfacing or deep peels to induce collagen production. Superficial radiofrequency devices and microneedling can help as well and are less invasive. I suggest going to an experienced cosmetic dermatologist with expertise in lasers and fillers. Best, Dr. Emer

I suggest Volbella which is FDA approved as a lip filler.  This filler is very soft, pliable, and easily molded.  

This scar-like structure is very likely result of fusion during embryonic development of lip. In most people it is not visible like in your case. The simplest way to address it would be a trial with filler. If that works, application of nano-fat grafts may be considered. In person consultation with a board certified plastic surgeon with some experience with cleft lip surgery is recommended. Good luck.