Hi there, thanks for the questio Restylane Refyne is a new hyaluronic acid filler that was specifically designed to deliver longer-lasting, more natural appearing results. In clinical studies, Refyne showed a meaningful improvement in wrinkle severity for up to 12 months in the majority of patients. Every patient is different. The nature of your skin quality, skin care routine, other aesthetic treatment, the rate of your metabolism and other factors may affect the duration of results. I often find that touch-up treatments are required for the most durable results. Additionally, a healthy lifestyle and effective skin care routine may help protect your results. Whenever you decide to move forward with treatment, make sure to seek out an experienced, board certified aesthetic dermatologist who can help you understand your options and safely perform the procedure.