Is laser genesis in combination with microdermabrasions an effective treatment?

Without close up photos or examine you in person, it is hard to say. Both laser genesis and microdermabrasion are good for treating the top layers of the skin. However, if your lines and wrinkles are caused by volume loss and sagging muscle then you'd probably be better served with fillers and Botox. Schedule a consultation with a board certified plastic surgeon to be assessed and discuss.

Laser genesis and microderm combinations are slightly effective to treat texture and redness. If you have actual lines and wrinkles, which are from volume loss, neither of these treatments, alone or together, are going to help much with that. Both of these treatments only reach the very upper layers of the skin, and lines are wrinkles are at much deeper depths. "This
answer has been solicited without seeing this patient and cannot be
held as true medical advice, but only opinion. Seek in-person treatment
with a trained medical professional for appropriate care."