Dear Admin, Cancer is very unlikely in the small, soft mobile lipomas on the arms, legs and torso that most people have. The very large ones, giant lipomas have an increased risk of being liposarcoma, and those rapidly growing, or having abnormalities of skin appearance. If there are multiple lipomas, 2-100's these are unlikely to be liposarcomas, which are single. Putting it the other way around, a cancer can arise in a lipoma but lipomas are by definition, benign tumors. Case Reports Dermatol Surg . 2004 Mar;30(3):463-7. doi: 10.1111/j.1524-4725.2004.30022.x. Giant lipomas: a series of 12 consecutive cases and a giant liposarcoma of the thigh Ahmet Terzioglu 1 , Doğan Tuncali, Ayşe Yuksel, Ferruh Bingul, Gürcan Aslan Affiliations expand PMID: 15008886 DOI: 10.1111/j.1524-4725.2004.30022.x