Dear Lynn2569:I have used Kybella (deoxycholic acid) successfully to treat lipomas. It is an off-label use of this medication, as are many medical and surgical treatments. Some of the original studies of deoxycholic acid involved the treatment of lipomas. The treatment of lipomas may have a different outcome than the treatment of fat in subcutaneous tissues, since fat cells in layers of fat, which are not proliferating, are eliminated permanently, whereas fat cells in lipomas, which start small and enlarge over time until they become stable, may still be proliferating. We have not had enough time to learn if they eventually enlarge with this treatment.All the best, Dr. Clark