Hello, To answer your excellent question, yes, PicoSure can definitely remove your colorful hand tattoo. PicoSure is very powerful technology and your result will definitely depend on the level of expertise of the provider you choose. PicoSure can treat all ink colors on all skin types and is very powerful on ink while is gentle on your skin to significantly decrease your chance of scarring. The black ink will likely fade first before the colorful ink will start disappearing. Please be prepared and patient during this process as it usually takes about 6-8 sessions, 6-8 weeks apart in between sessions. It is always highly advised to choose board certified physician to perform these kind of treatments, especially on your hands. If you go to someone who does not know what they are doing, they might burn you, scar you or even cause a hand infection, which is concidered to be one of medical emergencies requiring hospitalization. Hope this helps. Best of luck, Dr. Avaliani