How do I get rid of this laugh line on one side of my face? Nothing seems to be working. (Photo)

Unfortunately, your doctor is using the old-fashioned technique of simply "chasing after lines and wrinkles" with a simple filler, rather than addressing the underlying, age-related problem of volume loss in the upper and mid-cheek regions that is really behind the development and deepening of the smile lines. Frontal and profile views of your face encompassing a bit more of your cheeks would have given a clearer picture of what needs to be done to improve your smile lines and diminish the incipient jowl formation visible towards the sides of the corners of your mouth. Nevertheless, it does appear that volume loss of the malar cheek pad along with its downward and inward descent are contributing to the appearance of what troubles you. Merely treating the smile lines directly with a plain filler, like simple Juvederm ( which is intended for fine lines and wrinkles), was not likely to lead to either a satisfying or long-lasting result, and can sometimes even make things appear worse, as seems to be the case here. The appropriate way to address this problem is by dealing with the source of the problem--i.e. loss of volume in the malar cheek pads above and perhaps in the mid-face region to a lesser extent, as well. This can be easily accomplished, in a matter of minutes these days via the injection of a volumizing filler, such as Voluma XC (which would be my choice in my Upper East Side Manahattan practice) or Stylage XXL (my choice for this in my Israel satellite facility, where a far greater number of regulatory agency approved injectable volumizing fillers are available). The results of treatment in this fashion, which can be expected to last up to two years, would also appear natural, since they result from directly dealing with underlying problem that has given rise to the smile lines. As an added plus, the overall aging look of the mid-face would very likely be significantly improved, as well. Make sure you consult with a board certified aesthetic physician with experience and expertise in nonsurgical facial contouring, shaping and framing with volumizing fillers. Be sure to insist upon seeing his/her before and after photos before agreeing to proceed. Best of luck.

I recommend fillers to soften the nasolabial folds themselves and also lift around the mouth and cheeks to build underlying anatomical support. In our practice we combine Sculptra with other fillers "layered" on top and lasers, skin tightening treatments such as Thermage, Fractora, and Renuvion (J Plasma), thread lifting, and peels to get the most conservative, natural look. I suggest seeing a facial sculpting expert for a formal consultation. Best, Dr. Emer

Laugh Line Treatment is common and includes fillers in the actual line but also in your cheeks.  It would be important to examine you in animation and also at rest so that the treatment can be customized to your individual anatomy.  One thing to remember is that all these treatments soften the lines but will not remove the entirely.  There has to be a balance between achieving a natural result without looking over filled.  Also, it would be good to inquire about preventive things you can do such as sleeping on your back instead of on your side if you do.  Side sleeping can accentuate the lines and wrinkles o the face.Good Luck