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Accutane interferes with healing and can increase the risk of scarring with laser treatments, dermabrasion, and likely, tattoos. It is not recommended to have such elective procedures while on the treatment, and it would be wise to wait at least a year after the accutane course.
I do not recommend any elective procedures 24 months after Accutane as the risk of hypertrophic scarring or keloids is high. That includes tattoos, dermabrasions, laser procedures, etc. When a procedure is required, such as removal of a malignant or suspicious lesion from the skin, then there is no choice. But if you have the opportunity to wait, you will decrease the risk of scarring.
Some tattoo artists won't even perform the service on you if you're on Accutane, but besides that, some experts believe that Accutane does affect your body's ability to heal. So the skin may not heal as quickly as it would if you weren't on Accutane, and thus may increase your possibility for infection from the tattoo. I would recommend waiting at least 2 weeks after you finish your course of Accutane. Some might even say 6 months to a year. But I would say at least 2 weeks. Stay on your course of Accutane, though; don't go off it to get a tattoo.
Are you sure that what you have is angular cheilitis and not cold sores? That would be my first thought posed. If it is angular cheilitis, you most likely need some sort of antifungal medication, steroid, etc. If it's cold sores, you would need to go on Acyclovir (Zovirax). That being said,...
I believe Accutane can treat mild phyma, or prevent recurrence of phyma. For moderate to sever rhinophyma, the treatment of choice is laser. The does of Accutane you are on is high (60mg), and if your rhinophyma is worsening, I would consider laser. You do need a wash out period of 3-6 months...
Small gaps up to a month or little longer have no significant impact on the end results of the therapy as long the total dose of the treatment is eventually achieved. It is the total dose not the daily dose that seems to be the determining factor in achieving long lasting control of acne...