How many syringes of Juvederm to treat the nasolabial smile lines or would something else yield better results? Laser? (Photo)

Finding a permanent solution for lines around the mouth is challenging. There are many options such as filler injections, chemical peels, laser treatments (Nonablative as well as resurfacing) and of course mid face lifting and short scar face lifting.  It really depends on what you're specifically interested in and they're all sorts of combinations.
I would recommend that you see a board-certified plastic surgeon in your area that is a member of both ASPS & ASAPS and performs a lot of facelift surgery but also offers all the nonsurgical options such as injectables and laser treatments. Go over your concerns with them and make sure above all, you walk out of there with several options and an idea of the pros and cons to each of them as well as realistic expectations.I hope my answer helps and if it does, please take a moment to up vote this answer on the “respond” button on the top right.  Have a great day.

The wonderful thing about fillers is that you can go slowly until you achieve your desired result.  From your photos it appears you will need more than one syringe to address the nasolabial area.  You may consider adding filler to the cheeks as well for a more complete look.  Fillers work well when combined with other treatments such as microneedling, lasers, and chemical peels to address skin tone and texture.