Hello, and thank you for your question about whether Chantix (varenicline) is safe to use before and after a lower body lift and medial thigh lift. First, congratulations on your commitment to quitting smoking — that’s a major step toward ensuring a smooth surgery and recovery. To answer your question: Yes, you can typically continue using Chantix before and after surgery, as long as you are not actively smoking. Chantix is a prescription medication that works by blocking nicotine receptors in the brain, reducing cravings and withdrawal symptoms. It does not contain nicotine, so unlike nicotine patches, gum, or vaping, it will not constrict blood vessels or impair wound healing — which is the main reason plastic surgeons require patients to be nicotine-free before surgery. Your surgeon’s requirement that you be completely smoke-free for 30 days prior to surgery is very important, especially for procedures like a lower body lift and medial thigh lift, which have long incisions and require optimal blood flow for healing. Smoking or any nicotine use can cause wound breakdown, skin necrosis, infection, and poor scarring — especially in areas with tight closures like the groin or buttocks. As long as you stay off cigarettes, nicotine patches, gum, and vaping, Chantix should be safe to continue. In fact, your primary care doctor is right to recommend staying on it after surgery to help with stress and avoid relapse — quitting smoking around the time of surgery can be emotionally challenging, and Chantix may help you stay on track. Of course, always follow up with your plastic surgeon before surgery to confirm they are comfortable with you staying on Chantix during the perioperative period. Every surgeon has their own protocols, but in most cases, Chantix is not a contraindication for surgery. Wishing you a successful surgery and continued success staying smoke-free — both are investments in your long-term health and confidence! Sincerely, Dr. J. Timothy Katzen, MD, MBA, FASMBS, FICS (Certified by the American Board of Plastic Surgery and President of the American Society of Bariatric Plastic Surgeons; Fellow of the International Society of Aesthetic Plastic Surgery, American College of Surgery, International College of Surgery, and American Board of Metabolic and Bariatric Surgery; Member of the American Society of Plastic Surgeons, American Academy of Cosmetic Surgery, and RealSelf Hall of Fame) You're making all the right moves — quitting smoking, preparing for surgery, and using Chantix under supervision. Be proud of this step forward.