Dear jeanellemarie: Botox, Dysport and Xeomin are injectible muscle relaxers used to rebalance facial expression. Neuro-muscular moderators are very different than fillers Restylane and Juvederm. These are hyaluronic acid gels which create volume, projection and wrinkle reduction. Rheumatic or auto-immune include illnesses such as Lupus, Scleroderma, Sjogren's syndrome and others. Raynaud's Syndrome is a vasospastic syndrome which affects the extremities and not the face. Injections should be delayed during times of active skin inflammation including: acne, rosecia, viruses, and dermatitis as this may allow introduction of injection during a time the skin cannot handle both the infection and the skin disease. An antiseptic such as alcohol, betadine or hibiclens is recommended as well. Consult with your treating physician and have them communicate with your Board Certified Injecting Plastic Surgeon to reduce your risks, side-effects and obtain your best results! I hope this helps! All the best.