One side of face has deep crease, can this be fixed with filler? (photo)

Although it is perfectly normal to have some asymmetry in your face, it can be distracting especially if you are self conscious about it. Dermal fillers such as Juvederm and Restylane are very simple solutions but temporary. You may want to try one of these fillers first to make sure you like the way it looks then you can go for a longer lasting solution such as Bellafill® or a fat transfer. 

ReganI appreciate your concern but your asymmetry is mild and mostly noticeable when your smile. For this reason, I recommend correction with a filler like Juvederm Ultra plus by an experienced injector very conservatively because over correction will cause another asymmetry. If you like the result, then you can consider fat transfer for a longer lasting result. Seek out a board certified plastic surgeon or dermatologist with lots of experience treating lips. Good luck!