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The best way to clean aligners is with these effervescing tablets. Invisalign offers their own brand which can be quite pricey. I suggest to my patients to use either Efferdent or Polident denture cleansers. One patient told me that apple cider vinegar works great. I've treated myself with Invisalign, and I simply brushed my teeth after eating and then brushed the aligners before reinserting them into my mouth.