Both yes and no are correct, as noted below by my colleagues. If you are on a high dose of Accutane and your skin is very dry, irritated, and red, then no, you should probably not have one as the skin is too sensitive. However, if you are on a lower dose and maintaining fine but just a little dry, then a hydrating Silkpeel is ok. I would make sure your provider knows not to use the glycolic solution on you as that will be too much no matter your dose, but a nice Vitamin C or Hydrating, will be just fine. We do this daily in our office for people on low dose Accutane regimens with great success. "This answer has been solicited without seeing this patient and cannot be held as true medical advice, but only opinion. Seek in-person treatment with a trained medical professional for appropriate care."