Botox not effective - I am told I "metabolize" this too quickly

Question

For several years Botox worked quite well for my forehead and eye wrinkles. About 2 years ago it stopped working. I have also tried Xiomen and Dysport with the same poor result. Do you think Myobloc might work? And, is it possible that if I try Botox again, - it may work? It has been about a year since I last tried Botox. Thank you!!

Monika Kiripolsky, MD · Answer

Hi Katherine,  Research studies have shown that even patients who have antibodies to Botox associated complexes circulating in their bloodstream can still respond to its effects. I'd actually try going to a different provider and trying Botox again. There are many factors that can affect the efficacy of Botox's effects and your provider may have diluted it too much, had it sitting on the shelf for too long, bought it from a source not directly from Allergan, or not used enough units on you.   Dysport and Xeomin are also options, but, I'd actually try switching providers at this point.  Hope this helps!Dr. Kiripolsky

Sheila S. Nazarian, MD · Answer

My only suggestion would be to try another doctor. Your issue is not unheard of, but bottom line, Myobloc isn't going to make a difference. However, a higher dosage of Botox may help. Consult with a different board certified plastic surgeon in your area to discuss. Good luck --

Harold J. Kaplan, MD · Answer

Hi Katherine.  In the last 10-15 years we have only seen 2 or 3 patients with your set of circumstances.  These patients were not getting short duration or an allergic type reaction, they were just not getting the same results as everyone else.  So, what you are describing is possible.The only way to know for sure is to go to a new provider and try a higher dose.  It should not matter if it is Botox, Dysport or Xeomin as long as the does is high enough.  We would not recommend Myobloc as we have used this on those patients as well and it did not make a difference.  Los Angeles Dysport before and after photos at the link below.

Carmina Cardenas, MD · Answer

My recommendation will be to use BOTOX only and be sure,  you let pass at least 3-4 months in between dosis.Your body may create antibodies and never see results of any type of Botulinum Toxin (Botox, Xiomeen, Dysport etc) ever again.Be encouraged.Dr. Cardenas

Jason Emer, MD · Answer

I would considering using dysport or xeomin or using much higher levels of botox if you do not see the best results.  Best, Dr. Emer.

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Botox not effective - I am told I "metabolize" this too quickly

Answers (10)

Answer: Botox and antibodies

Answer: Botox and antibodies

Answer: Botox and No Improvement

Answer: Botox and No Improvement

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Our mission is to create a world where every investment in modern beauty is Worth It.