Dear drkatie2, Thank you for your interesting clinical post. Serrapeptase is an enzyme derived from silk worms. It has anti-inflammatory facts and can help dissolve blood clots, but these are somewhat unreliable and sometimes Serrapeptase is used in synchronist cancer therapy to minimize the risk of blood clots. However, I am not aware of any clinical studies that would have validated the effect of Serrapeptase on soft tissue fillers. Just judging from its chemical structure and how it acts, I do not believe it will act like Hyaluronidase, which can dissolve the hyaluronic acid sugar gel such as Restylane, Juvederm and Teoxane. Depending on your facial filler, be it of by a stimulatory such as Sculptra, Articol or Radiesse. The anti-inflammatory effects of Serrapeptase may have some limiting role or modulating role on the ability of your body to form collagen around these biostimulatories, but existing soft tissue fillers that are established and in place whether the sugar gels or the biostimulatories, I do not believe that the Serrapeptase will result in significant loss of the soft tissue filler effect. This is, however, only conjecture based upon incomplete knowledge of Serrapeptase effects on facial fillers and you may seek the advise of the doctor prescribing the Serrapeptase in the first place. Although not completely satisfying, I hope this information has been at least helpful. For more information, please review the link below. R. Stephen Mulholland, M.D. Certified Plastic Surgeon Yorkville, Toronto