For the past few years, the emphasis in nonsurgical facial rejuvenation with injectable fillers and volumizing agents is "deep support volumetry" to contour the face in three dimensions. Aging of the face involves the loss of fat from various fat compartments, including the cheeks, temples, lips, and chin, along with loss of bone and cartilage--all of which lead to sagging and jowl formation. Loss of cheek fat and cheek bone recession, particularly in the mid-facial region leads secondarily to the development of nasolabial folds. Since loss of volume in the cheeks is the primary cause of the development of the smile folds, directly replenishing the volume to the cheeks can not only restore the proper projection and light reflection to the cheeks themselves, but can secondarily help to soften the smile lines themselves, often without the need for directly injecting them (something that was common practice when I first began treating wrinkles over thirty years ago with the original Zyderm and Zyplast collagen fillers). In my Upper East Side Manhattan office I would opt to use Voluma XC and Radiesse for this purpose. In my Israel satellite facility, where a far greater number of regulatory agency approved fillers and volumizers are available I would opt for Stylage XXL and Emervel Volume.Nowadays experienced, expert physician injectors do not simply chase after wrinkles by filling them. Like sculptors, they must instead attempt to balance and contour the face by restoring the lost volume to the places where that volume existed earlier in life. In fact, when it comes to the smile lines, filling them directly and erasing them can give rise to an unnatural look--to what has been referred to as the "simian look," the flat-faced central face of a monkey. Once the appropriate 3D contouring has been achieved by volumization, individual etched-in wrinkle lines, such as may occur in the nasolabial folds after years of emoting, can be smoothed, if so desired, through the use of a superficial filler (rather than a more robust volumizing filler).