Will Dysport results be the same if the sodium chloride is diluted with half water?

.Dysport is provided as a freeze-dried powder which needs to be reconstituted using sterile saline. The initial trials were performed with preservative free saline which hurts more with injection then does preserved saline. Preserved saline has been shown to maintain the efficacy of dysport, Botox, and Xeomin. I am not aware of any data in which bacteriostatic water as opposed to saline was used to reconstitute neuromodulators. I also am not clear what the motivation would be to do this. Perhaps you can explain a little bit more why you're asking this question

I always mix my Dysport with 1ml of bacteriostatic saline. I've found that injection with bacteriostatic saline does not cause as much irritation as when it is mixed with plain saline. It does not make any sense to dilute it with half saline and half water. Plus, that is not FDA approved.

The FDA approved product to resuspend the lyophilized neurotoxins (Botox or Dysport) is saline for injection. Clinically, physicians found that using bacteriostatic saline hurts less. So, most physicians now use preserved saline. However, water is not FDA approved for use with this product and it is not clear to me what purpose using half water would serve.

Dysport should be diluted with sodium chloride and not water or a mixture of the two.  Most physicians prefer to use bacteriostatic sodium chloride.  

Thank you for your question. I dilute my Dysport with bacteriostatic NS as it causes less discomfort. Best,Benjamin J. Cousins MDBoard Certified Plastic Surgeon

In theory, the answer to your question is yes.  It should not make a difference if you dilute with both bacteria static water and sodium chloride.  Research has shown that neuromodulator (Botox, Dysport, Xeomin) mixed with bacteriostatic sodium chloride is less painful when injected into a patient.  My personal experience is similar to what the research has shown. Your question is unusual for a patient.  Please consult an experienced board certified dermatologist or plastic surgeon to attain consistent results. Best of luck,Suneel Chilukuri, M.D.Houston, TX

Your physician should know how to dilute properly. But to answer your question, Dysport should be mixed with bacteriostatic sodium chloride because it hurts less. Using anything else triggers a stinging upon injection and most people find it just about unbearable for a few minutes. "This answer has been solicited without seeing this patient and cannot
be held as true medical advice, but only opinion. Seek in-person
treatment with a trained medical professional for appropriate care."