Hi, Botox is a muscle relaxant/paralyzer toxin. It freezes muscles from moving. The loose crepey skin will not get much improvement with botox, other than the temporary swelling that you may have for the first few days after injection. The swelling from the injection will likely make the crepey skin look plumper and better, but as soon as the swelling from the injection goes away it will look the same. I am a facelift and necklift specialist. A face and necklift can help with the muscle bands (platysmal bands) and help to remove the loose skin, but the crepey neck skin is not really changed in any substantial way, other than having less neck skin which places the neck skin on some "stretch" when the patient is in a good posture and at "attention." However, if the patient lowers their chin or slouches, the skin on the lower half of the neck can still be crepey, because the necklift does not operate on the lower half of the neck. In the first 3-6 months after a face and necklift, the crepey skin on the lower half of the neck can look better, because the swelling from a face and neck surgery can last several months. This causes the skin of the lower half of the neck to be "plumper" and at least during this "honeymoon" period, the skin indeed, does look less crepey. However, as the term states, this is "honeymoon" swelling and when the swelling finally goes away, the crepey skin returns. For energy based procedures such as a J-plasma or Morpheus, this can also create 2-4 weeks of "honeymoon swelling" which is enough time for a early positive review of the procedure. However, after the "honeymoon" has passed, the skin may look the same ideally and not have overheated the fat under the skin in this area, to further shrink the fat, which might possibly make the skin even more crepey. For this reason, I am very concerned and critical with non-surgical energy based procedures possibly cooking the subcutaneous fat and making the problem worse. If the "honeymoon" give us any clues to the direction we should go in regards to actually improving the crepey skin, it should be in the direction of "plumping" and away from "cooking" the skin. The plumping idea is also catching on in the decolletage (upper chest area) which can also be crepey when the person slouches and the upper chest skin is pushed together. This is when the crepey skin is most visible. Now doctors are injecting Sculptra, Fat transfer, HA fillers as well as a newly FDA approved fat-like injectable called Renuva. I hope you found this response helpful. Good luck. Best, Dr. Yang