What are the risks of hyaluronidase?

Hyaluronidase is an enzyme which accelerates the absorption of hyaluronic acid based dermal fillers. When used in small quantities it can help to smooth bumpy areas after cosmetic filler injection. When restricted to overfilled areas, the response can take a few days to be noticeable. It does not seem to cause any degeneration of the surrounding normal tissue when used in this manner.

It is not FDA approved for this purpose as no clinical trials have ever been conducted. This is an off label use for a drug which has been used for other purposes for decades.

The main risk with hyaluronidase includes the possibility of reducing normal tissue instead of just filler.  The key is to use an appropriate concentration of hyaluronidase and seek an experienced injector.  Best Dr. Anil Shah

Hyaluronidase is a very safe injectable that can reverse the effects of hyaluronic acid based dermal fillers.  I would recommend that you only visit with an experienced plastic surgeon or dermatologist injector as this is a very nuanced injection technique.  It can be fairly rapid in onset and will not effect the tissue surrounding the injectable filler.  More often, a patient is not asking for complete reversal but rather to address specific concerns associated with their prior injection.