Dear Pink, Both tests are at or above the normal levels for women, and should be followed up by your doctor or referral to a hematologist to see if repeat blood tests are the same or higher. Both could be normal, but adversely affect the risk of blood clots. If your surgery is something with a higher risk of blood clots, like a tummy tuck, or a longer surgery, or you have other risk factors for blood clots, then the elevated rbc and platelet count is even greater cause for concern. Discuss all of this with your doctor, follow recommendations. Until the cause is determined, there is no reason to proceed with elective (optional) surgery. AI Overview A platelet count of 450,000 per microliter (μ L) of blood or higher is defined as thrombocytosis. While it is at the very top end of the normal range (150,000–450,000), it often indicates a temporary reaction to inflammation, infection, or iron deficiency. It generally signifies that your body is producing extra platelets, requiring further investigation to rule out chronic conditions.Key Aspects of a 450,000+ Platelet Count:Most Common Cause (Reactive/Secondary): Often a transient response to an underlying condition such as infection, tissue damage, surgery, or iron deficiency. These usually resolve when the underlying cause is treated.Persistent Levels (Primary/Clonal): If levels remain high or rise significantly higher, it may indicate a bone-marrow disorder known as Essential Thrombocythemia (ET).Potential Risks: While a slightly elevated count may cause no symptoms, high levels can increase the risk of blood clots, which can lead to complications such as stroke or deep vein thrombosis.Signs to Monitor: Consult a doctor if you experience symptoms like unexplained bruising, headaches, dizziness, or chest pain.Next Steps: A doctor will likely order a follow-up test, as a single high reading does not automatically indicate a serious disorder.