Having an MTHFR gene variant does not automatically mean you cannot have a BBL, especially if you have never had blood clots, pregnancy losses, bleeding problems, or other medical complications. The key is whether that finding is clinically significant for you, such as elevated homocysteine levels or a personal or family history of clotting. Before surgery, tell your plastic surgeon and anesthesia team exactly which MTHFR variant you have and share any lab work. They may want medical clearance, blood work, or in some cases input from a hematologist. For BBL specifically, safety also depends on your BMI, overall health, surgical time, VTE prevention plan, and a surgeon who follows modern BBL safety standards, including fat placement only in the subcutaneous layer. If your evaluation is normal and your surgeon feels the risk is controlled, you may still be a candidate, but this should be cleared before booking or proceeding.